Russian Journal of Woman and Child Health
ISSN 2618-8430 (Print), 2686-7184 (Online)

Routine laboratory tests for staging of cervical cancer. Novel potentialities

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DOI: 10.32364/2618-8430-2021-4-3-229-237

N.I. Stuklov1,2, T.V. Sushinskaya2, S.V. Epifanova3, E.V. Shchepkina4, A.I. Kuznetsov5

1Medical Institute of the Russian University of Peoples’ Friendship, Moscow, Russian Federation

2P. Hertsen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation

3Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation

4LLC "Techdepartament", Khimki, Russian Federation

5Moscow Aviation Institute (National Research University), Moscow, Russian Federation

Aim: to identify and assess novel potentialities of routine lab tests to improve the accuracy of preoperative staging (spread) of high-grade squamous intraepithelial lesions (HSIL) and cervical cancer (CC).

Patients and Methods: 410 women aged 18–82 (median age 42 [34; 51] years) with verified HSIL or CC were enrolled. Women were selected through medical records. Test results were monitored during in-person examinations since the formulation of clinical diagnosis and after surgical staging. If no surgical staging was performed, histopathology and disease stage as established by protocol examinations using instrumental and lab tests were considered. Women were subdivided into groups based on disease stage and method of treatment. Several parameters (complete blood count, hemostasis, biochemical markers of iron metabolism) were measured. In HSIL, minimal mandatory instrumental tests included pelvic and regional lymph node ultrasound. In CC stage 1–4, pelvic and abdominal ultrasound, pelvic MRI, abdominal CT with contrast, and (sometimes) PET CT.

Results: several routine parameters of peripheral blood (hemoglobin, RBCs, ESR, fibrinogen, soluble fibrin monomer complexes/SFMC, D-dimer, ADP-induced platelet activation) were identified. Changes in the levels of these parameters within/above/below reference ranges illustrate the systemic effect of malignancy on the body and are a significant marker of regional metastasis of CC undiagnosed during a clinical examination.

Conclusion: complex assessment of these parameters in CC allows for suspecting metastasis and requires more careful and reasonable examinations to improve the accuracy of prehospital diagnosis and determine management strategy.

Keywords: HSIL, cervical cancer, diagnosis, metastases, hematological markers, hemostasis, peripheral blood parameters, disease stage.

For citation: Stuklov N.I., Sushinskaya T.V., Epifanova S.V. et al. Routine laboratory tests for staging of cervical cancer. Novel potentialities. Russian Journal of Woman and Child Health. 2021;4(3):229–237 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-229-237.




About the authors:

Nikolay I. Stuklov — Dr. Sc. (Med.), professor of the Department of Hospital Therapy with the Courses of Endocrinology, Hematology, & Clinical Laboratory Diagnostics, Medical Institute of the Russian University of Peoples’ Friendship; 8, Miklukho-Maklaya str., Moscow, 117198, Russian Federation; Head of the Course of Hematology; principal researcher, P. Hertsen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre; 3, 2nd Botkinskiy pass., Moscow, 125284, Russian Federation; ORCID iD 0000-0002-4546-1578.

Tatyana V. Sushinskaya — C. Sc. (Med.), senior researcher, P. Hertsen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre; 3, 2nd Botkinskiy lane, Moscow, 125284, Russian Federation; ORCID iD 0000-0001-8812-9105.

Svetlana V. Epifanova — C. Sc. (Med.), radiologist of the Department of X-ray Diagnostics & Tomography, Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs; 15, Marshal Timoshenko str., Moscow, 121359, Russian Federation; ORCID iD 0000-0002-7591-5120.

Elena V. Shchepkina — C. Sc. (Soc.), Director for Statistics, LLC "Techdepartament"; 2, German Titov str., Khimki, 141407, Russian Federation; ORCID iD 0000-0002-2079-1482.

Anton I. Kuznetsov — student of the Faculty "Control Systems, Informatics, & Electricity", Moscow Aviation Institute (National Research University); 4, Volokolamskoe road, Moscow, 125993, Russian Federation; ORCID iD 0000-0003-2182-5792.

Contact information: Tatyana V. Sushinskaya, e-mail: talgi65@yandex.ru.

Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.

There is no conflict of interests.

Received 09.07.2021.

Revised 30.07.2021.

Accepted 24.08.2021.


References
1. Kaprin A.D., Starinsky V.V., Petrova G.V. Malignant neoplasms in Russia in 2018 (morbidity and mortality). M.: MNIOI im. P.A. Herzen — filial FGBU "NMIC radiologii" Minzdrava Rossii; 2019 (in Russ.).
2. Prato B., Ghelardi A., Gaducci A., Marchetti I. Correlation of recurrence rates and times with posttreatment human papillomavirus status in patients treated with loop electrosurgical excision procedure conization for cervical squamous intraepithelial lesions. Int J Gynecol Cancer. 2008;8:90–94. DOI: 10.1111/j.1525-1438.2007.00965.x.
3. Dostalek L., Slama J., Fisherova D. et al. Impact of sentinel lymph node frozen section evaluation to avoid combined treatment in early-stage cervical cancer. Int J Gynecol Cancer. 2020;30(6):744–748. DOI: 10.1136/ijgc-2019-001113.
4. Tsunoda A.T., Marnitz S., Soares Nunes J. et al. Incidence of histologically proven pelvic and para-aortic lymph node metastases and rate of upstaging in patients with locally advanced cervical cancer: results of a prospective randomized trial oncology. 2017;92(4):213–220. DOI: 10.1159/000453666.
5. Sedlis A., Bundy B.N., Rotman M.Z. et al. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study. Gynecol Oncol. 1999;73(2):177–183. DOI: 10.1006/gyno.1999.5387.
6. Landoni F., Colombo A., Milani R. et al. Randomized study between radical surgery and radiotherapy for the treatment of stage IB–IIA cervical cancer: 20-year update. J Gynecol Oncol. 2017;28(3):e34. DOI: 10.3802/jgo.2017.28.e34.
7. FIGO Committee on Gynecologic Oncology. Revised FIGO staging for carcinoma of the cervix uteri. Int J Gynecol Obstet. 2019;145(1):129–135. DOI: 10.1002/ijgo.12611.
8. Bhowmick N.A., Moses H.L. Tumor-stroma interactions. Curr Opin Genet Dev. 2005;15:97–101. DOI: 10.1016/j.gde.2004.12.003.
9. Clinical recommendations "Cervical Cancer". 2020. (Electronic resource.) URL: http://www.consultant.ru/document/cons_doc_LAW_348760/ (access date: 06.20.2021) (in Russ.).
10. Brierley J., Gospodarowicz M.K., Wittekind Ch. TNM classification of malignant tumours. Oxford, UK; Hoboken, NJ: John Wiley and Sons, Inc.; 2017.
11. Cormier B., Diaz J.P., Shih K. et al. Establishing a sentinel lymph node mapping algorithm for the treatment of early cervical cancer. Gynecol Oncol. 2011;122(2):275–280. DOI: 10.1016/j.ygyno.2011.04.023.
12. Louis-Sylvestre C., Evangelista E., Leonard F. et al. Sentinel node localization should be interpreted with caution in midline vulvar cancer. Gynecol Oncol. 2005;97(1):151–154. DOI: 10.1016/j.ygyno.2004.12.013.
13. Salvo G.1., Ramirez P.T., Levenback C.F. et al. Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer. Gynecol Oncol. 2017;145(1):96–101. DOI: 10.1016/j.ygyno.2017.02.005.
14. Abdel-Razeq H.N. Cancer-related anemia. Saudi Med J. 2004;25(1):15–20. PMID: 14758372.
15. Marchal C., Rangeard L., Brunaud C. Impact de l’anémie sur les traitements des cancers du col utérin (Anemia impact on treatments of cervical carcinomas). Cancer Radiother. 2005;9(2):87–95. DOI: 10.1016/j.canrad.2005.01.004.
16. Stuklov N.I., Kozinets G.I., Levakov S.A., Ogurtsov P.P. Anemia in gynecological and oncogynecological diseases. M.: MIA; 2013 (in Russ.).
17. Falanga A., Russo L., Milesi V., Vignoli A. Mechanisms and risk factors of thrombosis in cancer. Crit Rev Oncol Hematol. 2017;118:79–83. DOI: 10.1016/j.critrevonc.2017.08.003.
18. Somonova O.V., Mazhuga A.V., Elizarova A.L. Thrombosis and thromboembolism in Oncology. Gazeta Rossiyskogo obshchestva klinicheskoy onkologii. 2015;4:13–15 (in Russ.).
19. Sushinskaya T.V., Stuklov N.I., Dobrokhotova Yu.E. Diagnostic significance of screening studies of the hemostatic system for the staging of cervical cancer. Thrombosis, hemostasis and rheology. 2018;2(74):99–104 (in Russ.). DOI: 10.25555/THR.2018.1.0843.
20. Kochetov A.G., Liang O.V., Masenko V.P. et al. Methods of statistical processing of medical data: Guidelines for residents and postgraduates of medical schools, researchers. M.: RKNPC; 2012 (in Russ.).



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