Russian Journal of Woman and Child Health
ISSN 2618-8430 (Print), 2686-7184 (Online)

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art

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DOI: 10.32364/2618-8430-2020-3-3-174-181

I.N. Zakharova1, S.V. Mal’tsev1, V.V. Zubkov2, V.A. Kur’yaninova3, A.V. Dmitriev4, L.I. Mal’tseva5, N.E. Verisokina3, L.Ya. Klimov3, E.N. Vasil’eva6, S.I. Malyavskaya7, A.L. Zaplatnikov1

1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation

2V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation

3Stavropol State Medical University, Stavropol, Russian Federation

4Ryazan State Medical University, Ryazan, Russian Federation

5Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation

6I.N. Ul’yanov Cheboksary State University, Cheboksary, Russian Federation

7North State Medical University, Arkhangelsk, Russian Federation

This paper reviews the effects of vitamin D deficiency on pregnant women and newborns. It was demonstrated that vitamin D deficiency in pregnant women is associated with higher risks of threatened preterm labor, placental insufficiency, preeclampsia, gestational diabetes, bacterial vaginosis, and impaired uterine contractility as well as higher rate of C-sections. Vitamin D insufficiency in newborns is associated with inadequate bone mineralization and also results in metabolic disorders, hypocalcemic seizures, bronchopulmonary dysplasia, necrotic enterocolitis, sepsis, mental and developmental disorders, and higher risks of various (infectious, allergic etc.) disorders. Optimal vitamin D dosing regimen in pregnant women and newborns is discussed.

Keywords: pregnancy, vitamin D, vitamin D insufficiency, newborn, complications of pregnancy, preeclampsia, gestational diabetes.

For citation: Zakharova I.N., Mal’tsev S.V., Zubkov V.V. et al. Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art. Russian Journal of Woman and Child Health. 2020;3(3):174–181. DOI: 10.32364/2618-8430-2020-3-3-174-181.

About the authors:

Irina N. Zakharova — Doct. of Sci. (Med.), Professor, Head of Academician G.N. Speranskiy Department of Pediatrics, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0003-4200-4598.

Stanislav V. Mal’tsev — Doct. of Sci. (Med.), professor of Academician G.N. Speranskiy Department of Pediatrics, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0002-6203-2134.

Viktor V. Zubkov — Doct. of Sci. (Med.), Professor, Director of the Institute of Neonatology & Pediatrics, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4, Academician Oparin str., Moscow, 117997, Russian Federation, ORCID iD 0000-0001-8366-5208.

Viktoriya A. Kur’yaninova — Cand. of Sci. (Med.), associate professor of the Department of Propaedeutics of Children’s Diseases, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0002-0731-7153.

Andrey V. Dmitriev — Doct. of Sci. (Med.), Associate
Professor, Head of the Department of Children’s Diseases with the Course of Hospital Pediatrics, Ryazan State Medical University, 9, Vysokovol’tnaya str., 390026, Russian Federation; professor of Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0002-8202-3876.

Larisa I. Maltseva — Doct. of Sci. (Med.), professor of the Department of Obstetrics & Gynecology, Kazan State Medical University — Branch of the Russian Medical Academy of Continuous Professional Education, 49, Butlerov str., Kazan, 420012, Russian Federation, ORCID iD 0000-0003-0999-4374.

Natal’ya E. Verisokina — assistant of the Department of Faculty Pediatrics, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0001-5444-8351.

Leonid Ya. Klimov — Doct. of Sci. (Med.), Associate Professor, Dean of the Pediatric Faculty, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0001-7248-1614.

Elvira N. Vasil’eva — Cand. of Sci. (Med.), Associate Professor, associate professor of the Department of Obstetrics & Gynecology, I.N. Ul’yanov Cheboksary State University, 15, Moskovskiy av., Cheboksary, 428015, Russian Federation, ORCID iD 0000-0002-7677-7735.

Svetlana I. Malyavskaya — Doct. of Sci. (Med.), Professor, Head of the Department of Pediatrics, North State Medical University, 51, Troitskiy av., Arkhangelsk, 163000, Russian Federation, ORCID iD 0000-0003-2521-0824.

Andrey L. Zaplatnikov — Doct. of Sci. (Med.), Professor, Head of Prof. N.N. Gavryushov Department of Neonatology, professor of Acad. G.N. Speranskiy Department of Pediatrics, Vice-chancellor for Instructional Work, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0003-1303-8318.

Contact information: Andrey L. Zaplatnikov, e-mail: zaplatnikov@mail. ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 18.08.2020, revised 01.09.2020, accepted 15.09.2020.

1. Eremkina A.K., Mokrysheva N.G., Pigarova E.A., Mirnaya S.S. Vitamin D: influence on the course and outcomes of pregnancy, fetal development and children’s health in the postnatal period. Therapeutic archive. 2018;10:115–127 (in Russ.). DOI: 10.26442/ terarkh20189010115-127.

2. Maltsev S.V., Mansurova G. Sh., Zakirova A.M. et al. The role of vitamin D in the mother-placenta-fetus system. Practical medicine. 2016;1(93):26–31 (in Russ.). 3. Vinkhuyzen A.A., Eyles D.W., Burne T.H. et al. Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study. J Steroid Biochem Mol Biol. 2016;164:161–167. DOI: 10.1016/j.jsbmb.2015.09.018.
4. Hollis B.W., Wagner C.L. New insights into the vitamin D requirements during pregnancy. Bone Res. 2017;5;17030. DOI: 10.1038/boneres.2017.30.
5. Karras S.N., Wagner C.L., Castracane V.D. Understanding vitamin D metabolism in pregnancy: from physiology to pathophysiology and clinical outcomes. Metabolism. 2018;86:112–123. DOI: 0.1016/j.metabol.2017.10.001. 6. Grayson R., Hewison M. Vitamin D and human pregnancy. Fetal Matern Med Rev. 2011;22(1):67–90. DOI: 10.1017/S0965539511000039.
7. Savchenko T.N., Shcheplyagina L.A., Dobrochotova Y.E. et al. Vitamin D is a marker of womens immune status with miscarriage of infectious genesis. Terra Medica. 2016;1–2:43–46 (in Russ.).
8. Liu N.Q., Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys. 2012;523(1):37–47. DOI: 10.1016/
9. Nguyen T.P., Yong H.E., Chollangi T. et al. Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction. J Mol Med. 2015;93:795–805. DOI: 10.1007/s00109-015-1267-1.
10. Kiely M.E., Zhang J.Y., Kinsella M. et al. Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status. Am J Clin Nutr. 2016;104:354–361. DOI: 10.3945/ajcn.116.130419.
11. Shilin D.E. Calcium, vitamin D and formation of a healthy skeleton. M.; 2008 (in Russ.).
12. Magnus P., Birke C., Vejrup K. et al. Cohort profile update: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol. 2016;45(2):382–388. DOI: 10.1093/ije/dyw029.
13. Dawodu A., Tsang R.C. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Adv Nutr. 2012;3(3):353–361. DOI: 10.3945/an.111.000950.
14. Al-Beltagi M., Rowiesha M., Elmashad A. et al. Vitamin D status in preterm neonates and the effects of its supplementation on respiratory distress syndrome. Pediatr Pulmonol. 2020;55(1):108–115. DOI: 10.1002/ppul.24552.
15. Wuertz C., Gilbert P., Baier W., Kunz C. Cross-sectional study of factors that influence the 25-hydroxyvitamin D status in pregnant women and in cord blood in Germany. Br J Nutr. 2013;110:1895–1902. DOI: 10.1017/S0007114513001438.
16. Maltseva L.I., Polukeeva A.S., Garifullova Yu.V. The importance of vitamin D for women’s health and reproductive potential. Practical medicine. 2015;1(86):26–31 (in Russ.).
17. Zhang Y., Gong Y., Xue H. et al. Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect. BJOG. 2018;125(7):784–793. DOI: 10.1111/1471-0528.15060.
18. Yoon H.K. Gestational diabetes mellitus, fetal growth and vitamin D. J Bone Metab. 2017;24(3):155–159. DOI: 10.11005/jbm.2017.24.3.155.
19. Zhang C., Qiu C., Hu F.B. et al. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One. 2008;3(11): e3753. DOI: 10.1371/journal.pone.0003753.
20. Purswani J.M., Gala P., Dwarkanath P. et al. The role of vitamin D in pre-eclampsia: a systematic review. BMC Pregnancy Childbirth. 2017;17(1):231. DOI: 10.1186/s12884-017-1408-3.
21. Maltseva L.I., Vasilyeva E.N., Denisova T.G., Garifullova Yu.V. Influence of vitamin D on the course and outcomes of pregnancy in women. Practical medicine. 2020;3:17–22 (in Russ.).
22. Maltseva L.I., Vasilyeva E.N., Denisova T.G. Vitamin D and preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2016;16(1):79–83 (in Russ.). DOI: 10.17116/rosakush201616179–83.
23. Vasilyeva E.N., Maltseva L.I., Denisova T.G., Gerasimova L.I. Therapeutic significance of vitamin D and calcium in reducing the risk of preeclampsia. Obstetrics, Gynecology and Reproduction. 2019;13(2):103–110 (in Russ.). DOI: 10.17749/2313-7347.2019.13.2.103-110.
24. Dror D.K., Allen L.H. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev. 2010;68(8):465–477. DOI: 10.1111/j.1753-4887.2010.00306.x.
25. Vasil’eva E.N., Mal’tseva L.I., Denisova T.G., Gerasimova L.I. Health features of newborns depending on vitamin d level of their mothers during pregnancy. Kazan medical journal. 2017;98(5):691–696 (in Russ.). DOI: 10.17750/KMJ2017-691.
26. Zayachnikova T.E., Belan E.B., Krasilnikova A.S. Vitamin D deficiency in the mother-placenta-fetus system as a risk factor for physical and neurological developmental disorder in premature infants. RMJ. Medical Review. 2019;5:20–25 (in Russ.).
27. Yılmaz B., Aygün C., Çetinoğlu E. Vitamin D levels in newborns and association with neonatal hypocalcemia. J Matern Fetal Neonatal Med. 2018;31(14):1889–1893. DOI: 10.1080/14767058.2017.1331430.
28. Qin L.L., Lu F.G., Yang S.H. et al. Does maternal vitamin D deficiency increase the risk of preterm birth: a meta-analysis of observational studies. Nutrients. 2016;8(5):301. DOI: 10.3390/nu8050301.
29. Onwuneme C., Martin F., McCarthy R. et al. The association of vitamin D status with acute respiratory morbidity in preterm infants. J Pediatr. 2015;166(5):1175–1180. DOI: 10.1016/j.jpeds.2015.01.055.
30. Zia Z., Hashemi Z., Moghtaderi M. et al. The effect of maternal vitamin D deficiency on increased risk for hyperbilirubinemia in term newborns. Int J Pediatr. 2020;8(4):11141–11147. DOI: 10.22038/ijp.2019.42133.3548. 31. Yang L.R., Li H., Yang T.Y. et al. Relationship between vitamin D deficiency and early-onset neonatal sepsis. Chinese Journal of Contemporary Pediatrics. 2016;18(9):791–795 (in Chinese).
32. Ozdemir A.A., Cag Y. Neonatal vitamin D status and the risk of neonatal sepsis. Pak J Med Sci. 2019;35(2):420–425. DOI: 10.12669/pjms.35.2.342.
33. Hollis B.W., Wagner C.L. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013;92(2):128–139. DOI: 10.1007/s00223-012-9607-4.
34. Zakharova I.N., Klimov L.Ya., Kasyanova A.N. et al. The role of antimicrobial peptides and vitamin D in the formation of anti-infective protection. Pediatrics. 2017;96(4):171–179 (in Russ.). DOI: 10.24110/0031-403X-2017-96-4-171-179.
35. Tylavsky F., Kocak M., Murphy L. et al. Gestational vitamin 25(OH)D status as a risk factor for receptive language development: a 24-month, longitudinal, observational study. Nutrients. 2015;7(12):9918–9930. DOI: 10.3390/nu7125499.
36. Pludowski P., Grant W.B., Bhattoa H.P. et al. Vitamin D status in Central Europe. Int J Endocrinol. 2014;2014:1–12. DOI: 10.1155/2014/589587.
37. Pludowski P., Holick M.F., Grant W.B. et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125–135. DOI: 10.1016/j.jsbmb.2017.01.021.
38. Palacios C., De-Regil L.M., Lombardo L.K., Peña-Rosas J.P. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol. 2016;164:148–155. DOI: 10.1016/j.jsbmb.2016.02.008.
39. Malyavskaya S.I., Karamyan V.G., Kostrova G.N., Lebedev A.V. Assessment of vitamin D level in the umbilical cord blood of the Arkhangelsk city infants born in winter time. Russian Bulletin of Perinatology and Pediatrics. 2018;63(1):46–50 (in Russ.). DOI: 10.21508/1027-4065-2018-63-1-46-50.
40. Klimov L. Ya., Dolbnya S.V., Kuryaninova V.A. et al. Vitamin D levels in newborns children of Stavropol region. Medical Bulletin of the North Caucasus. 2015;10(2):159–163 (in Russ.). DOI: 10.14300/mnnc.2015.10037.
41. National program "Vitamin D deficiency in children and adolescents of the Russian Federation: modern approaches to correction". M.: Pediatrician; 2018 (in Russ.).
42. Anderson-Berry A., Thoene M., Wagner J. et al. Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population. PLoS One. 2017;12(10):1–15. DOI: 10.1371/journal.pone.0185950.
43. Agostoni C., Buonocore G., Carnielli V.P. et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50(1):85–91. DOI: 10.1097/MPG.0b013e3181adaee0.
44. Saggese G., Vierucci F., Prodam F. et al. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr. 2018;44:1–40. DOI: 10.1186/s13052-018-0488-7.
45. Abrams S.A. Committee on Nutrition. Calcium and vitamin D requirements of enterally fed preterm infants. Pediatrics. 2013;131(5):1676–1683. DOI: 10.1542/peds.2013-0420.
46. Cho S.Y., Park H.К., Lee H.J. Efficacy and safety of early supplementation with 800 IU of vitamin D in very preterm infants followed by underlying levels of vitamin D at birth. Ital J Pediatr. 2017;43:1–8. DOI: 10.1186/s13052-017-0361-0.
47. Kunz C., Hower J., Knoll A. et al. No improvement in vitamin D status in German infants and adolescents between 2009 and 2014 despite public recommendations to increase vitamin D intake in 2012. Eur J Nutr. 2019;58(4):1711–1722. DOI: 10.1007/s00394-018-1717-y.
48. Detrimax® baby. Instruction. (Electronic resource). URL: (access date: 21.08.2020).

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