Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art
I.N. Zakharova1, S.V. Mal’tsev1, V.V. Zubkov2, V.A. Kur’yaninova3, A.V. Dmitriev4, L.I. Mal’tseva5, N.E. Verisokina3, L.Ya. Klimov3, E.N. Vasil’eva6, S.I. Malyavskaya7, A.L. Zaplatnikov1
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation
3Stavropol State Medical University, Stavropol, Russian Federation
4Ryazan State Medical University, Ryazan, Russian Federation
5Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation
6I.N. Ul’yanov Cheboksary State University, Cheboksary, Russian Federation
7North State Medical University, Arkhangelsk, Russian Federation
This paper reviews the effects of vitamin D deficiency on pregnant women and newborns. It was demonstrated that vitamin D deficiency in pregnant women is associated with higher risks of threatened preterm labor, placental insufficiency, preeclampsia, gestational diabetes, bacterial vaginosis, and impaired uterine contractility as well as higher rate of C-sections. Vitamin D insufficiency in newborns is associated with inadequate bone mineralization and also results in metabolic disorders, hypocalcemic seizures, bronchopulmonary dysplasia, necrotic enterocolitis, sepsis, mental and developmental disorders, and higher risks of various (infectious, allergic etc.) disorders. Optimal vitamin D dosing regimen in pregnant women and newborns is discussed.
Keywords: pregnancy, vitamin D, vitamin D insufficiency, newborn, complications of pregnancy, preeclampsia, gestational diabetes.
For citation: Zakharova I.N., Mal’tsev S.V., Zubkov V.V. et al. Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art. Russian Journal of Woman and Child Health. 2020;3(3):174–181. DOI: 10.32364/2618-8430-2020-3-3-174-181.
About the authors:
Irina N. Zakharova — Doct. of Sci. (Med.), Professor, Head of Academician G.N. Speranskiy Department of Pediatrics, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0003-4200-4598.
Stanislav V. Mal’tsev — Doct. of Sci. (Med.), professor of Academician G.N. Speranskiy Department of Pediatrics, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0002-6203-2134.
Viktor V. Zubkov — Doct. of Sci. (Med.), Professor, Director of the Institute of Neonatology & Pediatrics, V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4, Academician Oparin str., Moscow, 117997, Russian Federation, ORCID iD 0000-0001-8366-5208.
Viktoriya A. Kur’yaninova — Cand. of Sci. (Med.), associate professor of the Department of Propaedeutics of Children’s Diseases, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0002-0731-7153.
Andrey V. Dmitriev — Doct. of Sci. (Med.), Associate
Professor, Head of the Department of Children’s Diseases with the Course of Hospital Pediatrics, Ryazan State Medical University, 9, Vysokovol’tnaya str., 390026, Russian Federation; professor of Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0002-8202-3876.
Larisa I. Maltseva — Doct. of Sci. (Med.), professor of the Department of Obstetrics & Gynecology, Kazan State Medical University — Branch of the Russian Medical Academy of Continuous Professional Education, 49, Butlerov str., Kazan, 420012, Russian Federation, ORCID iD 0000-0003-0999-4374.
Natal’ya E. Verisokina — assistant of the Department of Faculty Pediatrics, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0001-5444-8351.
Leonid Ya. Klimov — Doct. of Sci. (Med.), Associate Professor, Dean of the Pediatric Faculty, Stavropol State Medical University, 310, Mira str., Stavropol, 355017, Russian Federation, ORCID iD 0000-0001-7248-1614.
Elvira N. Vasil’eva — Cand. of Sci. (Med.), Associate Professor, associate professor of the Department of Obstetrics & Gynecology, I.N. Ul’yanov Cheboksary State University, 15, Moskovskiy av., Cheboksary, 428015, Russian Federation, ORCID iD 0000-0002-7677-7735.
Svetlana I. Malyavskaya — Doct. of Sci. (Med.), Professor, Head of the Department of Pediatrics, North State Medical University, 51, Troitskiy av., Arkhangelsk, 163000, Russian Federation, ORCID iD 0000-0003-2521-0824.
Andrey L. Zaplatnikov — Doct. of Sci. (Med.), Professor, Head of Prof. N.N. Gavryushov Department of Neonatology, professor of Acad. G.N. Speranskiy Department of Pediatrics, Vice-chancellor for Instructional Work, Russian Medical Academy of Continuous Professional Education, 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation, ORCID iD 0000-0003-1303-8318.
Contact information: Andrey L. Zaplatnikov, e-mail: zaplatnikov@mail. ru. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 18.08.2020, revised 01.09.2020, accepted 15.09.2020.
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