Iron deficiency anemia in obstetrics
T.P. Zefirova1, E.Yu. Yupatov1, R.R. Mukhametova2
1Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation
2Kazan Federal University, Kazan, Russian Federation
This paper discusses the anemia of pregnancy that is a global issue affecting tens of millions of women. The prevalence of anemia increases as pregnancy progresses and is maximum in the third trimester having a negative impact on pregnancy course. Major causes of unfavorable perinatal outcomes related to anemia are addressed. The authors highlight that anemia of pregnancy increases the rate of stillbirths, premature birth, and intrauterine growth restriction. The mechanisms accounting for placental insufficiency (e.g., circulatory hypoxia, abnormal blood rheology, microcirculatory abnormalities) are described. Current data on the increased risk of maternal death in anemia are discussed. Its major causes are hemorrhages, infectious septic complications, and thromboses. Diagnostic and therapeutic modalities for anemia are emphasized. Personalized management strategy and rational choice of iron products require an understanding of iron metabolism and the knowing of the role of hepcidin-mediated inhibition of the mechanism of iron metabolism.
Keywords: iron deficiency anemia, pregnancy, maternal mortality, placental insufficiency, hep-cidin, pre-pregnancy preparation, hemodilution.
For citation: Zefirova T.P., Yupatov E.Yu., Mukhametova R.R. Iron deficiency anemia in obstetrics. Russian Journal of Woman and Child Health. 2021;4(1):53–58. DOI: 10.32364/2618-8430-2021-4-1-53-58.
About the authors:
Tat’yana P. Zefirova — Doct. of Sci. (Med.), professor of the Department of Obstetrics & Gynecology, Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education; 36, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0001-6785-6063.
Evgeniy Yu. Yupatov — Cand. of Sci. (Med.), Associate Professor, Head of the Department of Obstetrics & Gynecology, Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education; 36, Butlerov str., Kazan, 420012, Russian Federation; ORCID iD 0000-0001-8945-8912.
Renata R. Mukhametova — obstetrician & gynecologist, Kazan Federal University; 18, Kremlevskaya str., Kazan, 420008, Russian Federation.
Contact information: Tat’yana P. Zefirova, e-mail: email@example.com. Financial Disclosure: no authors have a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 04.11.2020, revised 27.11.2020, accepted 22.12.2020.
This work is licensed under a Creative Commons «Attribution» 4.0 License.